La myasthénie (ou maladie de Erb-Goldflam)
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Affection neuro-musculaire se manifestant par une fatigabilité anormale, due à un AC dirigé contre le récepteur de l’acéthyl-choline, il gène la contraction des fibres musculaires. Il s’ensuit une faiblesse et une fatigabilité musculaire rapide et anormale à l’effort. Fragilité souvent liée à des anomalies thymiques ou à d’autres maladies auto-immunes :
- de prédominance féminine, d’atteinte précoce : HLA A1/B8 + DR3,
- ou HLA masculin, d’atteinte plus tardive : A3/B7 et DR2.
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Peu de travaux ont été faits à la recherche d’un xéropeptide causal. Cependant STEFANSSON et coll. (1985) ont testé des anticorps antirécepteur de l’acétylcholine sur les protéines de 10 espèces bactériennes et ont constaté des homologies entre certaines régions du récepteur et certaines protéines d’Escherichia coli, de Klebsiella pneumoniae et de Proteus vulgaris.
- Phosphorus, Plumbum ou Manganum, Curare (mn) …
- Nosodes : Botulinum / CMV 200K
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Le syndrome de Gélineau ou « narcolepsie »
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La NARCOLEPSIE est un trouble du sommeil caractérisé par des accès d’endormissement survenant plusieurs fois par jour, attaques de sommeil répétées (mais ne durant pas plus de 10 minutes/heure), survenant n’importe quand et n’importe où ! La narcolepsy s’observe dans les deux sexes à une fréquence d’environ 1 cas pour 2,000 personnes. Ce syndrome apparaît dans l’enfance ou l’adolescence. Lié au HLA DR2. Ce syndrome s’associe, chez 75 % des patients à la cataplexie, souvent déclenchée par de fortes émotions. Aucun traitement ne cible les causes de la maladie, qui restent mal connues.
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L’apparition de 220 cas ont été répertoriés en Europe après vaccination H1N1, sinon on a noté des cas après la grippe espagnole (autre H1N1), une infection à CMV ou à Streptocoque B. C’est en fait une maladie auto-immune qui a pour cible les cellules à orexine de l’hypothalamus (HLA DQ 1). Ref. Hallmayer et coll. « Nature Genetics » 3 mai 2009.
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NARCOLEPSIE et HOMEOPATHIE
ANTIMONIUM CRUDUM
Strong inclination to sleep during the day, especially in the evening or morning. Sleepy and weary. Drowsiness, especially in elderly people. Deep unrefreshing sleep.
ANTIMONIUM TARTARICUM
Irresistible inclination to sleep. Great drowsiness. Excessive yawning. On falling asleep electric-like shocks. Cries during sleep with fixed eyes and trembling. Jerking up of limbs during sleep.
ARSENIC ALBUM
Drowsy and sleepiness in the daytime while sitting. Talks in sleep. Yawning and stretching of limbs. Awakened by pains. Shocks on dropping to sleep. Violent starting with twitching, trembling of limbs during sleep. Disturbed sleep at night with great restlessness.
CAUSTICUM
Sleepiness during the day, can scarcely resist it, must lie down. Yawning and stretching. Very drowsy, can hardly keep awake. Laughs and cries during sleep.
CHELIDONIUM MAJUS
Drowsiness, which is so marked even in the open air, that she is near falling asleep while walking. Falls asleep while speaking.
CIMEX LECTULARIUS
Great drowsiness falls asleep when sitting in the morning. Irresistible sleepiness during chill. Frequent yawning with cold feeling on skin.
CYCLAMEN
Great inclination to lie down, and to sleep. No desire to work. Great dejection and melancholy.
HYDROCYANIC ACID
Narcolepsy. Irresistible drowsiness. Yawning and shivering.
KALI BROMATUM
Extreme drowsiness. Drops asleep in char.
KALI NITRICUM
Drowsiness and sleepiness in day time. Disturbed sleep at night, constant dreaming, with frequent awakening.
MERCURIUS: Great sleepiness during the day, which is not relieved from long sleep.
NATRUM MURIATICUM
Sleepy in afternoon. Nervous jerking during sleep. Sobs during sleep. Sleepiness and drowsiness after meals.
NATRUM SULPH
Sleepiness during day, especially while reading.
NUX MOSCHATA
Narcolepsy. Irresistibly drowsy, sleepy, muddled, as if intoxicated. Great drowsiness and sleepiness. Sleepy attacks, sudden with vertigo. Great sleepiness with all complaints. Dreams of falling from high place of being pursued.
NUX VOMICA
Drowsy after meals and in early evening. Better after a nap, unless aroused. Yawning. Weeping and talking during sleep. Anxious dreams, pursued by animals, dogs, and cats.
OPIUM
Great drowsiness. Falls into heavy deep sleep.
PHYSOSTIGMA VENENOSUM
Attacks of overpowering sleepiness with feeling as if to lose consciousness.
PULSATILLA NIGRICANS
Irresistible sleepiness in afternoon. Great sleepiness during day, wakes confused, languid, unrefreshed. Sleepy while eating. Wide awake in the evening, first sleep restless. Lies with hands over head or crossed on abdomen and feet drawn up. Chattering in sleep. Talks, whines, or screams during sleep.
SABADILLA
Great inclination to sleep during day. Comes on when thinking, meditating, or reading. Agitated and unrefreshing sleep at night with anxious dreams. In the morning he starts up from his sleep as from a fright.
SEPIA
Great desire to sleep during daytime, falls asleep as soon as he sits down. Talks loudly during sleep.
ZINCUM METALLICUM
Narcolepsy. Sleep is broken and unrefreshing. Cries out while sleeping, body jerks, wakes frightened, startled. Loud screaming in sleep without being aware of it. Nervous motion of feet when asleep.
